https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475631/
Conclusion: Acne can cause scarring, as well as psychological disorders such as decreased self-esteem, depression, anxiety and even suicide (3). Nowadays, systemic antibiotics, isotretinoin and topical drugs are used for treatments of severe acne (4).
https://pubmed.ncbi.nlm.nih.gov/35668721/ Conclusion: According to epidemiologic explorations, acne affects 9.4% of the global population, making it the eighth most common disease globally. Acne perturbs up to 85% of adolescents, while it is periodically misconceived as an ailment that affects teenagers only; nonetheless, it also affects myriad adults. Acne has well-documented psychosocial ramifications, including adverse effects on self-perception, mental health, and social functioning. Acne leads to significant morbidity that is associated with residual scarring and psychological disturbances such as poor self-image, depression, and anxiety, which leads to a negative impact on quality of life.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132408/ Conclusion: Acne is a common but serious skin disease, which affects approximately 80% adolescents and young adults in 11–30 age group. 42.5% of men and 50.9% of women continue to suffer from this disease into their twenties. Bacterial resistance is now at the alarming stage due to the irrational use of antibiotics. Hence, search for new lead molecule/bioactive and rational delivery of the existing drug (for better therapeutic effect) to the site of action is the need of the hour. On the word of statistics, globally around 85% of young adults aged 12–25 years old experience certain degree of acne [9]. On an average 42.5% of men and 50.9% of women continue to suffer from the disease in their twenties [5]. One population study in Germany found that 64% of individuals 20 to 29 years old and 43% of individuals 30 to 39 years old had visible acne.
https://academic.oup.com/jcem/article/92/1/196/2598434?login=false Testosterone in men 1987-1997.
Conclusions: These results indicate that recent years have seen a substantial, and as yet unrecognized, age-independent population-level decrease in T in American men, potentially attributable to birth cohort differences or to health or environmental effects not captured in observed data.
https://sci-hub.se/downloads/2020-10-14/c4/lokeshwar2020.pdf Testosterone in men 1999-2016. We conclude that TT levels have been declining in young adult men in recent decades.
https://myparla.com/health-hub/fertility/decreasing-testosterone-levels/
22 year old man today, has an average testosterone level roughly equal to that of a 67 year old man in 2000
https://www.health.harvard.edu/newsletter_article/testosterone_aging_and_the_mind
Perhaps. The data are far from conclusive, but some studies suggest a link:
A 2005 study of 565 World War II veterans found that higher testosterone levels in midlife were linked to better preservation of brain tissue in some, but not all, regions of the brain in late life.
A 2004 study of 400 men age 40 to 80 found that higher testosterone levels were associated with better cognitive performance in older men. No link was observed in younger individuals.
A 2004 report from the Baltimore Longitudinal Study of Aging evaluated 574 men over a 19-year period. Low free testosterone levels predicted an increased risk of developing Alzheimer's disease, even after other dementia risk factors were taken into account.
A 2002 study of 310 men with an average age of 73 found that higher levels of bioavailable testosterone were associated with better scores on three tests of cognitive function.
A 2002 study of 407 men between the ages of 51 and 91 found that men with higher free testosterone levels achieved higher scores on four cognitive function tests, including visual and verbal memory.
A 1999 study of 547 men between the ages of 59 and 89 found that high testosterone levels in older men were associated with better performance on several cognitive function tests.
External toxins are also wreaking havoc with male hormones.
Chemicals (including parabens and phthalates) in our environment are disrupting our hormonal balance, causing various degrees of reproductive havoc on a daily basis. These are called hormone or endocrine disrupting chemicals – also known as EDC’s
They are undoubtedly playing a role in testosterone levels declining at 10% per decade. This decline has gone hand in hand with sperm health which has taken a similar negative trajectory with very worrying predictions for the next generation.
Only this week (March 2021), leading Epidemiologist Shanna Swan published a book outlining the serious global decline in male fertility stating that;
Testosterone and mood
Studies of testosterone and mood are in their infancy. Some research suggests that men with abnormally low testosterone levels, either because of hypogonadism (see below) or androgen deprivation therapy, have an increased incidence of depression, but other studies disagree. Small, short-term studies suggest that testosterone therapy may help alleviate symptoms of depression in some men but that very high doses may promote aggressive or manic behavior. All in all, the bottom line is familiar: More research is needed.